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Related Experiment Videos

Circulatory disturbances in multiple systems organ failure.

A Bersten1, W J Sibbald

  • 1Richard Ivey Critical Care Trauma Centre, Victoria Hospital, London, Canada.

Critical Care Clinics
|April 1, 1989
PubMed
Summary

Multiple system organ failure (MSOF) disrupts metabolic autoregulation, impairing oxygen delivery to tissues. This occurs across cardiac, regional, and microcirculatory levels, leading to inadequate oxygen supply in sepsis.

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Area of Science:

  • Physiology
  • Pathophysiology
  • Critical Care Medicine

Background:

  • Multiple system organ failure (MSOF) is a critical condition characterized by impaired metabolic autoregulation.
  • The ability to match tissue oxygen delivery with oxygen demand is essential for cellular function.

Purpose of the Study:

  • To summarize evidence linking MSOF to compromised tissue oxygen delivery.
  • To examine the circulatory disturbances at cardiac, regional, and microcirculatory levels in MSOF.

Main Methods:

  • Review of existing evidence on circulatory changes in MSOF.
  • Analysis of the impact of these changes on metabolic autoregulation and oxygen delivery.

Main Results:

  • MSOF is associated with circulatory disturbances affecting the heart, regional circulations, and microcirculation.

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  • These circulatory alterations collectively impair the body's ability to autoregulate tissue oxygenation.

    • Conclusions:

    • Circulatory dysfunction at multiple levels contributes to inadequate metabolic autoregulation in MSOF.
    • Reduced tissue oxygen delivery is a key consequence of these circulatory disturbances in sepsis.