Related Experiment Video
Updated: Mar 31, 2026
Pooled CRISPR-Based Genetic Screens in Mammalian Cells
Published on: September 4, 2019
caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens
Jan Winter1, Marco Breinig1, Florian Heigwer1
1German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Heidelberg, Germany and.
Motivation:
Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing.
Results:
The CRISPR-AnalyzeR for pooled screens (caRpools) is an R package for exploratory data analysis that provides a complete workflow to analyze CRISPR/Cas9 screens. To further support the analysis of large-scale screens, caRpools integrates screening documentation and generation of standardized analysis reports.
Availability And Implementation:
caRpools, manuals and an open virtual appliance are available at http://github.com/boutroslab/caRpools.
