Related Experiment Video
Updated: Mar 31, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
12.5K
INTERLEUKIN-6 GENE POLYMORPHISM MODULATES THE RISK OF PERIODONTAL DISEASES
L Scapoli1, A Girardi1, A Palmieri1
1Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Journal of Biological Regulators and Homeostatic Agents
|October 30, 2015
Summary
Interleukin-6 (IL6) gene polymorphisms influence susceptibility to gingivitis and periodontitis. Individuals with specific IL6 variants show reduced risk for these common periodontal diseases.
Area of Science:
- Genetics
- Periodontology
- Immunology
Background:
- Gingivitis and periodontitis are common inflammatory periodontal diseases with varying severity.
- Susceptibility to periodontal diseases is influenced by genetic factors affecting immune response and tissue homeostasis.
Purpose of the Study:
- To investigate the association between Interleukin-6 (IL6), Interleukin-10 (IL10), and Vitamin D Receptor (VDR) gene polymorphisms and periodontal diseases.
- To determine the role of these gene polymorphisms in the susceptibility to gingivitis and chronic periodontitis in an Italian population.
Main Methods:
- A case-control study involving 750 Italian patients diagnosed with gingivitis or chronic periodontitis.
- Genotyping of single nucleotide polymorphisms (SNPs) in the IL6, IL10, and VDR genes.
- Statistical analysis to assess the association between specific SNPs and disease occurrence.
Main Results:
- A significant association was found between the rs1800795 SNP in the IL6 gene promoter and both gingivitis and periodontitis.
- Individuals homozygous for the variant allele of rs1800795 showed decreased susceptibility to gingivitis (OR=0.47) and periodontitis (OR=0.36).
- No significant association was observed between IL10 or VDR gene polymorphisms and the studied periodontal diseases.
Conclusions:
- The IL6 gene polymorphism rs1800795 plays a role in the susceptibility to both gingivitis and chronic periodontitis in the Italian population.
- These findings highlight the involvement of IL6 in the pathogenesis of periodontal diseases.
- IL6 polymorphisms may not be a reliable biomarker for periodontitis due to its association with gingivitis as well.
Related Concept Videos
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
109
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
109
01:05Single Nucleotide Polymorphisms-SNPs
19.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.8K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
68
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
68
01:24T Cell Types and Functions
3.3K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.3K
01:27The Oral Microbiota
38
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
38