Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

479
Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
479
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

2.5K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
2.5K
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

450
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
450
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.9K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.9K
Pharmacodynamic Models: Overview01:27

Pharmacodynamic Models: Overview

83
Pharmacodynamic (PD) responses describe the interaction between a drug and its biological target, culminating in a physiological effect. These responses can be classified into different types: continuous variables, such as blood glucose levels; categorical outcomes, like survival rates; and time-to-event metrics, such as disease progression. Understanding and modeling PD responses are critical for optimizing drug efficacy and safety.PD models describe the relationship between drug concentration...
83
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

323
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
323

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity.

Medical physics·2026
Same author

Track event model is superior to linear quadratic cell survival model for predicting TCP of SBRT treatments of NSCLC.

Zeitschrift fur medizinische Physik·2026
Same author

Poisson Linear-Quadratic Tumor Control Probability Model Validation in Micro- and Macroscopic Breast Cancer Radiation Therapy.

International journal of radiation oncology, biology, physics·2025
Same author

Tumor geometry adjusted lattice structures for animal spatially fractionated SBRT.

Zeitschrift fur medizinische Physik·2025
Same author

Realistic closed-form TCP model including cell sensitivity dependence.

Physics in medicine and biology·2025
Same author

Development of heart-sparing VMAT radiotherapy technique incorporating heart substructures for advanced NSCLC patients.

Radiation oncology (London, England)·2025

Related Experiment Video

Updated: Mar 31, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.4K

Yes, we need mechanistic biophysical models!

Uwe Schneider, Jürgen Besserer

    Zeitschrift Fur Medizinische Physik
    |October 30, 2015
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
    16:27

    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

    Published on: September 14, 2011

    13.0K
    Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
    09:56

    Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

    Published on: December 23, 2022

    2.2K

    Related Experiment Videos

    Last Updated: Mar 31, 2026

    Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
    09:32

    Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

    Published on: April 11, 2018

    10.4K
    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
    16:27

    Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

    Published on: September 14, 2011

    13.0K
    Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
    09:56

    Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

    Published on: December 23, 2022

    2.2K