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Coronary and Basilar Artery Ectasia Are Associated: Results From an Autopsy Case-Control Study

Fernando Pico1, Julien Labreuche1, Jean-Jacques Hauw1

  • 1From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).

Stroke
|October 31, 2015
PubMed

Insights

Intracranial artery dolichoectasia (IADE) and coronary artery ectasia are linked. This autopsy study found coronary artery ectasia in 8 IADE stroke patients, suggesting a common cause for these vascular conditions.

Area of Science:

  • Neurology
  • Cardiology
  • Pathology

Background:

  • Intracranial artery dolichoectasia (IADE) is linked to stroke.
  • Coronary artery ectasia is linked to myocardial infarction.
  • Coexistence of IADE and coronary artery ectasia is rare.

Purpose of the Study:

  • Investigate the association between IADE and coronary artery ectasia.
  • Examine this association in a large autopsy series.
  • Determine if a common pathogenesis exists.

Main Methods:

  • Identified 16 stroke patients with IADE from 381 stroke patients.
  • Matched IADE patients with 16 stroke patients without IADE.
  • Examined hearts and coronary arteries using a prespecified protocol.

Main Results:

  • Coronary artery ectasia found in 8 of 16 IADE stroke patients (P=0.008).
  • No coronary artery ectasia observed in stroke patients without IADE.
  • Positive correlation between basilar and right coronary artery diameters (r=0.51; P=0.003).

Conclusions:

  • Autopsy study suggests a common pathogenesis for IADE and coronary artery ectasia in stroke patients.
  • Findings highlight a potential link between intracranial and coronary artery disease.
Abstract

Keywords:
autopsycoronary vesselsmyocardial infarctionstrokevertebrobasilar dolichoectasia

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