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Published on: October 1, 2012
Synthesis and Biological Evaluation of Chlorinated Analogs of Leukotoxin Diol
Christian Nilewski1, Camille Le Chapelain1, Susanne Wolfrum1
1Vladimir Prelog Weg 3, Laboratory of Organic Chemistry, ETH-Zürich , CH-8093 Zurich, Switzerland.
Organic Letters
|October 31, 2015
Abstract:
This study documents that chlorinated analogs of leukotoxin diol 1, in which the vic-diol has been replaced with vic-chlorides (2), induce caspase 3 activity and apoptosis on HepG2 cells in a dose-dependent manner in analogy to the parent diol. This suggests that chlorides may substitute for hydroxyls in certain lipids as bioisosteres in defined biological settings.

