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Organising pneumonia due to dronedarone.
D Thornton1, S Avery, A J Edey
1ARL Medford, North Bristol Lung Centre & University of Bristol, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK. Email andrew.medford@nbt.nhs.uk.
The Journal of the Royal College of Physicians of Edinburgh
|October 31, 2015
Summary
Organising pneumonia, a lung injury response, can mimic bacterial pneumonia but doesn't respond to antibiotics. This case highlights dronedarone as a potential cause, emphasizing early drug identification for better outcomes.
Area of Science:
- Pulmonology
- Toxicology
- Pharmacology
Background:
- Organising pneumonia (OP) is a lung response to injury, often presenting similarly to bacterial pneumonia.
- OP does not respond to antibiotic treatment, necessitating identification of alternative causes.
- Drug-induced lung injury is a significant concern in clinical practice.
Observation:
- A 67-year-old male presented with organising pneumonia.
- The condition was diagnosed as secondary to dronedarone, an antiarrhythmic medication.
- Radiographic findings included peripheral consolidation on chest X-ray and perilobular consolidation on CT scans.
Findings:
- Dronedarone was identified as the causative agent for organising pneumonia in this patient.
- Early identification of drug-induced pneumotoxicity is crucial for patient management.
- Bronchoscopic biopsy may be challenging, but steroid therapy often yields rapid improvement after drug withdrawal.
Implications:
- Dronedarone should be considered in the differential diagnosis of drug-induced organising pneumonia.
- Clinicians should utilize resources like the Pneumotox database for suspected drug-related pneumotoxicity.
- Prompt recognition and management of drug-induced lung injury can prevent further morbidity and improve patient prognosis.
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