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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Mar 31, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Glaucoma risks in advanced corneal surgery.

Vincenzo Maurino1, Francesco Aiello2

  • 1Moorfields Eye Hospital, NHS Foundation Trust, London, UK.

Progress in Brain Research
|November 1, 2015
PubMed
Summary
This summary is machine-generated.

Glaucoma risk is lower with modern lamellar keratoplasty (DALK, DSAEK, DMEK) compared to penetrating corneal transplant (PKP) surgery. This is due to less invasive techniques and reduced steroid use, improving outcomes for corneal graft patients.

Keywords:
Anterior lamellar keratoplastyEndothelial keratoplastyGlaucomaPenetrating keratoplastySteroid-induced glaucomaUrrets-Zavalia syndrome

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Glaucoma Research

Background:

  • Penetrating corneal transplant (PKP) has been a long-standing treatment for corneal disease.
  • Lamellar keratoplasty techniques (DALK, DSAEK, DMEK) have emerged with advantages over PKP.
  • Glaucoma is a significant complication leading to visual loss and graft failure after corneal transplantation.

Purpose of the Study:

  • To review the incidence, causes, and management of glaucoma following corneal transplantation.
  • To compare glaucoma risk across different corneal graft procedures.
  • To discuss glaucoma development after other anterior segment surgeries.

Main Methods:

  • Review of literature on corneal transplantation and glaucoma.
  • Analysis of risk factors including steroid-induced intraocular hypertension and pre-existing glaucoma.
  • Comparison of glaucoma incidence between PKP and lamellar keratoplasty.

Main Results:

  • Lamellar keratoplasty demonstrates a reduced risk of glaucoma compared to PKP.
  • Lower glaucoma incidence in lamellar procedures is attributed to less invasive surgical methods and decreased postoperative steroid requirements.
  • Glaucoma can also occur after other anterior segment surgeries.

Conclusions:

  • Modern lamellar keratoplasty offers a lower risk profile for glaucoma post-surgery.
  • Careful management of intraocular pressure and steroid use is crucial in all corneal graft patients.
  • Understanding glaucoma's etiology and management is vital for optimizing visual outcomes.