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[Does sleep apnea disappear once acromegaly is adequately treated?]
M Bruyneel1, S Haumont2, F Devuyst2
1Service de pneumologie, CHU Saint-Pierre, 322, rue Haute, 1000 Bruxelles, Belgique.
Revue Des Maladies Respiratoires
|November 1, 2015
Summary
Acromegaly, a rare hormonal disorder from excess growth hormone, frequently causes obstructive sleep apnea. Treatment outcomes for this complication are unpredictable, varying from improvement to worsening in patients.
Area of Science:
- Endocrinology
- Sleep Medicine
- Internal Medicine
Background:
- Acromegaly is a rare endocrine disorder caused by excessive growth hormone (GH) secretion.
- GH excess leads to numerous complications, affecting cardiovascular, respiratory, metabolic, articular, and neoplastic systems.
- Obstructive sleep apnea syndrome (OSAS) is a common comorbidity in acromegaly patients.
Observation:
- The impact of acromegaly treatment on OSAS is variable.
- Observed outcomes include improvement, no change, or even deterioration of OSAS.
- This variability highlights the complex interplay between GH excess and sleep-disordered breathing.
Findings:
- This report details three clinical cases of acromegaly.
- The cases illustrate the unpredictable natural history and treatment response of OSAS in acromegaly.
- Patient responses to interventions for OSAS associated with acromegaly were inconsistent.
Implications:
- Understanding the variable course of OSAS in acromegaly is crucial for patient management.
- Further research is needed to identify predictors of OSAS evolution in acromegaly.
- Personalized treatment strategies may be required for acromegaly patients with OSAS.
Keywords:
AcromegalyAcromégalieAdénome hypophysaireContinuous positive airway pressurePituitary adenomaPression positive continueSleep apnea syndromeSyndrome des apnées du sommeilMore Related Videos
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