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Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
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Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
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Molecular Pathways: Fatty Acid Synthase.

Suzanne F Jones1, Jeffrey R Infante2

  • 1Sarah Cannon Research Institute, Nashville, Tennessee.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|November 1, 2015
PubMed
Summary
This summary is machine-generated.

Targeting tumor metabolism with fatty acid synthase (FASN) inhibitors is a promising new cancer therapy. Newer FASN inhibitors are advancing, with some entering clinical trials for cancer treatment.

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Area of Science:

  • Oncology
  • Cancer Metabolism
  • Drug Development

Background:

  • Cancer cells rely on lipid synthesis for growth and survival.
  • Fatty acid synthase (FASN) is crucial for producing lipids, making it a key oncologic target.
  • Targeting tumor metabolism represents a novel therapeutic strategy in oncology.

Purpose of the Study:

  • To review the role of FASN in cancer.
  • To discuss the development of FASN inhibitors as anticancer therapies.
  • To highlight the potential of FASN inhibition in clinical settings.

Main Methods:

  • Review of preclinical and clinical studies on FASN inhibitors.
  • Analysis of the pharmacologic properties and side-effect profiles of FASN inhibitors.
  • Identification of novel FASN inhibitors in development.

Main Results:

  • Early-generation FASN inhibitors faced limitations in pharmacology and side effects.
  • A new generation of FASN inhibitors, including TVB-2640, is under investigation.
  • TVB-2640 is the only FASN inhibitor that has advanced to clinical trials.

Conclusions:

  • FASN inhibition is a promising therapeutic approach for cancer patients.
  • Combination therapies involving FASN inhibitors may offer enhanced efficacy.
  • Further clinical investigation of FASN inhibitors is warranted.