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Updated: Mar 31, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
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Seeing through thick and through thin: Retinal manifestations of thrombophilic and hyperviscosity syndromes

Rithwick Rajagopal1, Rajendra S Apte1

  • 1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, Missouri, USA.

Survey of Ophthalmology
|November 1, 2015
PubMed

The presence of retinal vasculopathy in the absence of typical predisposing factors should suggest a possible underlying hematologic abnormality. In such cases, a systemic investigation may reveal a potentially fatal hypercoagulability or hyperviscosity syndrome. Retinal vein occlusion is the most commonly encountered ophthalmic finding in such syndromes; however, abnormalities of the arterial system, the choroid, and the macula are also possible. Visual symptoms may be the only manifestation of the underlying process, making timely diagnosis by the ophthalmologist critical for both treatment and thrombotic prophylaxis. Moreover, as newer ophthalmic diagnostic technologies arise, there is an increasingly important role for eye physicians in the management of such syndromes.

Keywords:
factor V Leidenhyperhomocysteinemiaindocyanine green angiographylymphoplasmacytic leukemiamacular edemapolycythemiaprothrombin G20210Aretinal vein occlusionserous choroidal detachment

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