The relationship between essential tremor and Parkinson's disease
Mary Ann Thenganatt1, Joseph Jankovic1
1Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Parkinsonism & Related Disorders
|November 3, 2015
Summary
Essential tremor (ET) and Parkinson's disease (PD) share overlapping symptoms and a potential link. Research explores the relationship between ET and PD, suggesting implications for understanding their shared pathogenic mechanisms and treatment strategies.
Area of Science:
- Neurology
- Movement Disorders
Background:
- Essential tremor (ET) and Parkinson's disease (PD) are common tremor disorders.
- While distinct, ET and PD can present with overlapping clinical features like bradykinesia and rigidity.
- A subset of patients may develop PD after a long history of ET (ET-PD).
Purpose of the Study:
- To review current evidence supporting a relationship between ET and PD.
- To discuss the implications of this relationship for pathogenesis and treatment.
Main Methods:
- Review of clinical studies
- Epidemiologic data analysis
- Imaging studies
- Genetic research
- Pathologic investigations
Main Results:
- Multiple lines of evidence suggest a link between ET and PD beyond chance.
- Overlapping symptoms and the ET-PD progression indicate a potential connection.
Conclusions:
- The relationship between ET and PD warrants further investigation.
- Understanding this link may offer insights into shared disease mechanisms.
- This knowledge could inform novel therapeutic approaches for both conditions.
Related Concept Videos
01:24Parkinson's Disease: Treatment
1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
01:15Parkinson's Disease: Overview
2.4K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.4K
01:37Neural Regulation
44.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.8K
01:15REM Sleep Behavior Disorder
2.5K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
2.5K
01:26Alzheimer's Disease: Overview
2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K