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Sunitinib loaded chitosan nanoparticles formulation and its evaluation.

Jayapal John Joseph1, D Sangeetha1, Thandapani Gomathi2

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Summary
This summary is machine-generated.

Chitosan nanoparticles (CS-NPs) were developed to deliver the anticancer drug Sunitinib (STB), showing potential for effective, sustained drug release. This novel nanocarrier system offers a promising approach for cancer therapy.

Keywords:
Chitosan nanoparticlesIonic crosslinkingSunitinib

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Chitosan nanoparticles (CS-NPs) are versatile nano-polymeric excipients for drug formulation.
  • Developing effective drug delivery systems is crucial for improving cancer therapy outcomes.

Purpose of the Study:

  • To synthesize and characterize Sunitinib-loaded chitosan nanoparticles (SNB-CS-NPs).
  • To evaluate the potential of SNB-CS-NPs as a novel drug delivery system for sustained Sunitinib release.

Main Methods:

  • Chitosan nanoparticles (CS-NPs) were synthesized using ionic cross-linking.
  • Formulation characterization involved Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), FT-IR, and X-ray Diffraction (XRD).
  • In vitro drug release and cytotoxic studies were conducted.

Main Results:

  • DLS confirmed SNB-CS-NPs were within the < 200 nm size range.
  • UV spectrophotometry validated Sunitinib encapsulation.
  • In vitro studies demonstrated sustained drug release and cytotoxic effects.

Conclusions:

  • The synthesized SNB-CS-NPs represent a viable nano-polymeric drug delivery system.
  • This formulation shows promise for effective and sustained delivery of Sunitinib for cancer treatment.