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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

Functional cerebral blood volume mapping with simultaneous multi-slice acquisition.

Laurentius Huber¹, Dimo Ivanov², Maria Guidi³

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; sFIM, NIMH, NIH, Bethesda, MD, USA.

|November 3, 2015

Summary

This summary is machine-generated.

Simultaneous multi-slice (SMS) EPI enhances vascular space occupancy (VASO) mapping, enabling greater brain coverage for blood volume measurements. This advanced technique offers improved specificity to gray matter tissue compared to GE-BOLD.

Keywords:

7Tesla MRI Multi-band SS-SI VASO Simultaneous multi-slice Vascular space occupancy cerebral blood volume

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Published on: May 10, 2012

Area of Science:

Neuroimaging
Functional Magnetic Resonance Imaging (fMRI)
Vascular Physiology

Background:

Current multi-slice echo planar imaging (EPI) for vascular space occupancy (VASO) mapping has limitations in brain coverage.
Accurate measurement of blood volume responses is crucial for understanding brain function.

Purpose of the Study:

To overcome the brain coverage limitations of conventional VASO mapping.
To improve non-invasive functional measurements of blood volume responses using simultaneous multi-slice (SMS) EPI acquisition.

Main Methods:

Incorporation of SMS EPI acquisition into slice-saturation slab-inversion VASO (SS-SI VASO).
Acquisition of blood-volume-weighted VASO and gradient echo blood oxygenation level-dependent (GE-BOLD) data in humans at 7T using a 32-channel head coil.
Application of SMS-VASO in high-resolution and low-resolution scenarios for varied brain coverage.

Main Results:

SMS-VASO enabled robust detection of blood volume changes in up to 20 slices with short readout durations (<150ms).
High-resolution SMS-VASO demonstrated improved specificity to gray matter (GM) tissue, reducing contamination from large draining veins compared to GE-BOLD.
Demonstrated improved 3D coverage not achievable with standard VASO within the short null magnetization period.

Conclusions:

VASO fMRI with SMS-EPI significantly enhances 3D brain coverage for functional measurements.
The proposed method offers superior spatial specificity to GM tissue compared to GE-BOLD.
SMS-VASO is a promising technique for high-resolution human fMRI at 7T, advancing non-invasive brain imaging.