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Updated: Mar 30, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions.

Michel Baguette1, Delphine Legrand2, Virginie M Stevens3

  • 1Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France; Muséum National d'Histoire Naturelle, UMR 7205 ISYEB, F-75005, Paris, France.

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Multiple molecular variations interact nonlinearly to create complex phenotypic variations, challenging traditional views. This new framework offers insights into evolutionary phenotype production, integrating selection experiments and functional genetics.

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Area of Science:

  • Evolutionary biology
  • Genetics
  • Systems biology

Background:

  • Traditional models assume a hierarchical relationship between genotype and phenotype.
  • Phenotypic variation arises from complex interactions across multiple molecular levels.
  • Understanding these interactions is crucial for evolutionary studies.

Purpose of the Study:

  • To propose a new, individual-centered framework for understanding genotype-phenotype relationships.
  • To challenge the hierarchical view of genotypic and phenotypic spaces.
  • To provide new insights into the evolutionary mechanisms of phenotype production.

Main Methods:

  • Conceptual framework development.
  • Integration of selection experiments.
  • Application of functional genetics approaches.

Main Results:

  • A new framework viewing molecular variations as contributors to phenotypic variation in a complex, nonlinear, and interactive manner.
  • Challenging the hierarchical nature of genotypic and phenotypic spaces.
  • Providing novel insights into evolutionary mechanisms of phenotype production.

Conclusions:

  • The proposed framework offers a more nuanced understanding of genotype-phenotype relationships.
  • Future research should combine selection experiments and functional genetics to explore these complex interactions.
  • This approach advances the study of evolutionary mechanisms driving phenotypic diversity.