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Related Concept Videos

Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

1.4K
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
1.4K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.3K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.3K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.1K
Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

1.5K
Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
1.5K
Peripherally and Centrally Acting Muscle Relaxants: A Comparison01:09

Peripherally and Centrally Acting Muscle Relaxants: A Comparison

4.9K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
4.9K

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Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
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Spasticity Management After Stroke.

Francois Bethoux1

  • 1Mellen Center Rehabilitation Services, The Cleveland Clinic, 9500 Euclid Avenue/Desk U10, Cleveland, OH 44195, USA.

Physical Medicine and Rehabilitation Clinics of North America
|November 3, 2015
PubMed
Summary
This summary is machine-generated.

Poststroke spasticity, often with paresis, complicates recovery. While current treatments show effectiveness, more research is needed on functional outcomes and combined therapy impacts.

Keywords:
Outcome measuresRehabilitationSpasticityStrokeSymptom management

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Movement Disorders

Background:

  • Poststroke spasticity is a common complication affecting survivors.
  • Spasticity frequently co-occurs with other neurological deficits like paresis, complicating assessment.
  • Clinical examination, including resistance to passive movement and abnormal muscle contractions, is key for diagnosis.

Purpose of the Study:

  • To review the current understanding and management of poststroke spasticity.
  • To evaluate the evidence for commonly used spasticity treatments.
  • To identify gaps in knowledge regarding functional outcomes and combination therapies.

Main Methods:

  • Literature review of studies on poststroke spasticity assessment and treatment.
  • Analysis of evidence supporting pharmacologic and non-pharmacologic interventions.
  • Synthesis of findings on treatment effectiveness, safety, and functional impact.

Main Results:

  • Established evidence supports the efficacy and safety of many common spasticity medications.
  • Combined non-pharmacologic and pharmacologic approaches are frequently employed.
  • Challenges remain in evaluating treatment outcomes due to associated impairments.

Conclusions:

  • Current treatments for poststroke spasticity are generally effective and safe.
  • Further research is required to fully understand functional outcomes.
  • Investigating the impact of combined treatment modalities is crucial for optimizing patient recovery.