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Updated: Jun 20, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
The Intensive Stroke Cycling for Optimal Recovery and Economic Value Trial: Protocol for a Randomized Clinical Trial.
Courtney R Miller1, Dawn Taylor1,2, Francois Bethoux1
1Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Neurological Institute, Cleveland, OH 44195, United States.
Facilitated aerobic exercise (FE) may improve upper and lower extremity function after stroke. This trial investigates FE
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Exercise Physiology
Background:
- Current stroke rehabilitation for upper extremity (UE) and lower extremity (LE) function is resource-intensive.
- Preliminary data suggest facilitated aerobic exercise (FE) may enhance UE motor recovery post-stroke.
Purpose of the Study:
- To determine the effects of FE on UE and LE motor recovery in subacute stroke survivors.
- To elucidate the neural and biochemical mechanisms underlying FE-induced motor recovery.
- To evaluate the cost-effectiveness of a FE-centered intervention.
Main Methods:
- A prospective, single-center, randomized clinical trial involving 66 individuals with subacute stroke-related hemiparesis.
- Participants were randomized to FE plus abbreviated therapy (FE+rehab) or usual care therapy (rehab).
- Both groups received 90 minutes of intervention, twice weekly for 12 weeks.
Main Results:
- Motor outcomes will be assessed at baseline, end of treatment, and 6-month follow-up.
- Neural and biochemical markers (EEG, blood biomarkers) will be analyzed.
- Cost-effectiveness will be modeled for immediate and long-term economic impact.
Conclusions:
- FE shows potential for enhancing stroke survivor recovery cost-effectively.
- This approach could accelerate clinical adoption of new rehabilitation strategies.
- Mechanistic studies will explore FE's impact on neuroplasticity substrates.
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