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Updated: Mar 30, 2026
Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
Published on: April 1, 2015
Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple
Yuki Aoki1, Reiji Miyawaki, Kohsuke Imai
1Departments of *Pediatrics ‡Transfusion Medicine §Pharmacy, Tokyo Medical and Dental University (TMDU) ∥Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo †Department of Pediatrics, Uwajima City Hospital, Uwajima, Japan.
Abstract:
Outcome of children with acute lymphoblastic leukemia (ALL) has improved over the years, but not for those with multiple recurrences because of high therapy resistance and heavily pretreated history that potentially cause physical damages. We describe the case of an 11-year-old boy with a third relapse of ALL and a history of 2 allogeneic bone marrow transplantations. He was successfully treated with clofarabine combination chemotherapy and achieved a fourth remission at 16 months following haploidentical bone marrow transplantation with conditioning regimen of clofarabine and busulfan. Clofarabine/busulfan conditioning might be a preferable option for children with multiple recurrent ALL, and warrants further investigation.
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