Related Experiment Video
Updated: Mar 30, 2026
04:53
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
Published on: October 18, 2024
1.6K
Understanding asthma-chronic obstructive pulmonary disease overlap syndrome
Keele E Wurst1, Kaitlin Kelly-Reif2, Greta A Bushnell2
1GSK R&D, Research Triangle Park, NC, USA.
Respiratory Medicine
|November 4, 2015
Summary
Asthma-COPD overlap syndrome (ACOS) prevalence varies widely due to differing definitions. This review highlights the impact of diagnostic criteria on ACOS prevalence estimates in asthma and COPD patients.
Area of Science:
- Pulmonary Medicine
- Clinical Epidemiology
Background:
- Asthma-COPD overlap syndrome (ACOS) describes patients with features of both asthma and COPD.
- Lack of standardized definitions complicates ACOS understanding, impacting prevalence, diagnosis, and treatment.
- Previous research has not systematically explored how varying definitions affect ACOS prevalence estimates.
Purpose of the Study:
- To characterize the prevalence of ACOS.
- To evaluate the effect of different disease definitions on ACOS prevalence estimates.
Main Methods:
- Literature review of English language studies published between 2000 and 2014.
- Analysis of prevalence data for ACOS in patients with COPD and asthma.
- Comparison of prevalence estimates based on diverse diagnostic criteria and ascertainment methods.
Main Results:
- Estimated ACOS prevalence ranged from 12.1% to 55.2% in COPD patients.
- Estimated ACOS prevalence ranged from 13.3% to 61.0% in asthma patients.
- Variability in prevalence is associated with differences in diagnostic criteria, ascertainment methods (spirometry, clinical diagnosis, claims data), and population characteristics (age, gender, smoking status).
Conclusions:
- The wide range of ACOS prevalence estimates is significantly influenced by the specific diagnostic criteria and methods used.
- Clarifying ACOS definitions is crucial for accurate prevalence assessment and future clinical study design.
- Standardized criteria will aid in better understanding and managing ACOS patients.
Keywords:
AsthmaAsthma-chronic obstructive pulmonary disease overlap syndromeChronic obstructive pulmonary diseaseMore Related Videos
Related Concept Videos
01:24Chronic Obstructive Pulmonary Disease
3.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.2K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.1K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.1K
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.1K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.1K
01:26Asthma-II: Pathophysiology and Classification
4.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.9K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
4.1K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.1K