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Ethylene Oxide Measurements From OSHA Workplace Investigations: Patterns in Exposure by Industry, Occupation, and
Brian Christensen1, Matthew M Dahm1, I-Chen Chen1
1National Institute for Occupational Health and Health (NIOSH), Cincinnati, Ohio, USA.
American Journal of Industrial Medicine
|July 21, 2025
Summary
Occupational exposure to ethylene oxide (EtO) generally decreased over time but remains high in industrial sterilization. Many US workplace samples still exceed recommended limits, highlighting a need for better characterization and risk assessment.
Area of Science:
- Occupational Health
- Environmental Science
- Industrial Hygiene
Background:
- Ethylene oxide (EtO) is a known occupational carcinogen.
- Current EtO exposure levels in US workplaces are not well-documented.
- Historical OSHA data provides a basis for analyzing EtO exposure trends.
Purpose of the Study:
- To characterize EtO exposure trends in US workplaces.
- To analyze exposure patterns across different industries and occupations.
- To assess the proportion of exposures exceeding established occupational exposure limits.
Main Methods:
- Analysis of air sampling data from 1979 to 2020.
- Evaluation of exposure by industry and occupation.
- Examination of temporal changes in exposure levels.
- Quantification of non-compliance with occupational exposure limits.
Main Results:
- Overall decrease in EtO exposures over the study period.
- Inconsistent reduction patterns across industries.
- 46% of samples exceeded the NIOSH REL (0.1 ppm); 18% exceeded the OSHA PEL (1 ppm).
- 70% of industrial sterilization samples exceeded the NIOSH REL.
- Limited exposure data available for 2000-2020, particularly in health services and chemical manufacturing.
Conclusions:
- Contemporary EtO exposures are poorly characterized.
- Industrial sterilization shows higher and least-declined exposures.
- Further research in exposure and risk assessment is crucial for worker protection.

