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Published on: February 20, 2019
[The use of agomelatine (valdoxan) in gambling therapy: a pilot study]
1St. Petersburg State University, Medical Faculty, Department of Psychiatry and Addictions, Mechnikov Nord-West Medical University, Department of Psychiatry and Addictions, St. Petersburg, Sechenov Institute of Evolutionary Physiology and Biochemistry, Laboratory of Behaviour Neurophysiology and Pathology, St. Petersburg.
Objective:
To study the antidepressant agomelatine (M1/M2 agonist and 5-HT2C antagonist) in pathological gambling (PG) (ICD-10 item F63.0).
Material And Methods:
An open label 8-week trial was carried out in 22 outpatients (17 male and 5 female, mean age 38±7). PG severity was assessed by the Yale-Brown Obsessive-Compulsive Scale adapted for Pathological Gambling (PG-YBOCS). Anxiety and depression level was measured by the Hospital Anxiety Depression Scale (HADS).
Results:
Agomelatine significantly decreased PG-YBOCS scores from the second week of the trial (12.6±3.0 compared to 24.2±2.1 at baseline, p<0.05). In the end of the trial, PG-YBOCS score decreased to 5.3. The total HADS score decreased significantly in the end of the study (from 23.6±2.9 to 11.4±1.9, p<0.05). There was an improvement in behavior as well.
Conclusion:
Thus, agomelatine has demonstrated efficacy in PG patients.
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