The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS): Unifying Efforts to Inform Practice and...

Area of Science:

• Nephrology
• Clinical Research
• Public Health

Background:

• Extending technique survival in peritoneal dialysis (PD) is crucial for patient outcomes and increasing PD utilization.
• The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) aims to identify modifiable practices linked to improved PD technique and patient survival.
• Collaboration with the International Society for Peritoneal Dialysis (ISPD) standardizes data definitions and fosters international clinical research in PD.

Purpose of the Study:

• To identify modifiable practices associated with improved PD technique and patient survival.
• To standardize PD-related data definitions for international collaborative research.
• To establish a research platform for understanding variations in PD practices and outcomes.

Main Methods:

• An international prospective cohort study involving Australia, Canada, Japan, the UK, and the US.
• Enrollment of a random sample of incident and prevalent PD patients from 20-80 national sites.
• Collection of demographic, comorbidity, treatment, and patient-reported data over a 3-year follow-up period, with primary outcome of all-cause PD technique failure or death.

Main Results:

• A high proportion of targeted study sites have been recruited across participating countries.
• Ancillary studies have been funded, with momentum towards expansion into new countries and increased participation.
• The study is actively collecting data to establish a comprehensive dataset on PD practices.

Conclusions:

• PDOPPS is the first large-scale international study to longitudinally track PD patient clinical practices.
• The collected data will serve as a vital resource for the global PD community.
• The study aims to elucidate variations in PD practices, identify optimal approaches, and ultimately enhance patient outcomes.