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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Morphological, Functional, and Biological Vascular Healing Response 6 Months After Drug-Eluting Stent Implantation: A

Tsuyoshi Nakata1, Kenichi Fujii2, Masashi Fukunaga1

  • 1Cardiovascular Division, Hyogo College of Medicine, Nishinomiya, Japan.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|November 4, 2015
PubMed

Insights

Zotarolimus-eluting stents (ZES) and everolimus-eluting stents (EES) showed better vascular response than sirolimus-eluting stents (SES). Optical coherence tomography (OCT) findings may not fully represent endothelial healing after stenting.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • The representation of endothelial healing by optical coherence tomography (OCT) strut coverage after drug-eluting stent implantation remains unclear.
  • Evaluating coronary endothelial function post-stenting requires diverse methodologies.

Purpose of the Study:

  • To compare coronary endothelial function following implantation of sirolimus-eluting stents (SES), everolimus-eluting stents (EES), and zotarolimus-eluting stents (ZES).
  • To determine if OCT findings correlate with endothelial healing after stent implantation.

Main Methods:

  • Thirty patients with left anterior descending artery lesions were randomized to receive SES, EES, or ZES.
  • Vascular response was assessed at 6 months using acetylcholine infusion (functional), OCT (morphological), and vascular endothelial growth factor (VEGF) levels (biological).

Main Results:

  • ZES demonstrated a lower proportion of uncovered struts compared to SES and EES on OCT.
  • Sirolimus-eluting stents (SES) showed impaired vasomotor response and lower VEGF levels compared to EES and ZES.
  • No significant correlation was found between OCT findings and vasomotor response or VEGF levels.

Conclusions:

  • Zotarolimus-eluting stents (ZES) and everolimus-eluting stents (EES) exhibited better vascular response at 6 months compared to sirolimus-eluting stents (SES).
  • Morphological assessment via OCT may not serve as a reliable surrogate for functional and biological healing post-stenting.
Abstract

Keywords:
coronary artery diseasedrug-eluting stentsoptical coherence tomography

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