Related Experiment Video
Updated: Mar 30, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Mu opioid receptor polymorphism, early social adversity, and social traits
Charles S Carver1,2, Sheri L Johnson2,3, Youngmee Kim1,2
1a Department of Psychology , University of Miami , Coral Gables , FL , USA.
Abstract:
A polymorphism in the mu opioid receptor gene OPRM1 (rs1799971) has been investigated for its role in sensitivity to social contexts. Evidence suggests that the G allele of this polymorphism is associated with higher levels of sensitivity. This study tested for main effects of the polymorphism and its interaction with a self-report measure of childhood adversity as an index of negative environment. Outcomes were several personality measures relevant to social connection. Significant interactions were obtained, such that the negative impact of childhood adversity on personality was greater among G carriers than among A homozygotes on measures of agreeableness, interdependence, anger proneness, hostility, authentic pride, life engagement, and an index of (mostly negative) feelings coloring one's world view. Findings support the role of OPRM1 in sensitivity to negative environments. Limitations are noted, including the lack of a measure of advantageous social environment to assess sensitivity to positive social contexts.
More Related Videos
Related Concept Videos
Opioid Receptors: Overview
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Causes of Social Behavior III: Biological and Environmental Influences
Socioemotional Development during Infancy
Primary Temperament Types
Analgesia and Pain Management

