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Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
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ENCODE data at the ENCODE portal.

Cricket A Sloan1, Esther T Chan1, Jean M Davidson1

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The Encyclopedia of DNA Elements (ENCODE) Project is cataloging human genome functional elements using expanded assays. The new ENCODE Portal enhances data access, searchability, and integration for researchers.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • The Encyclopedia of DNA Elements (ENCODE) Project aims to identify all functional elements in the human genome.
  • Previous phases have generated substantial genomic data, necessitating improved accessibility and integration.

Purpose of the Study:

  • To detail the third phase of the ENCODE Project, focusing on expanded functional genomics assays.
  • To introduce the revamped ENCODE Portal for enhanced data discovery, access, and integration.

Main Methods:

  • Expansion of assays to measure diverse RNA populations, protein-RNA/DNA interactions, DNA hypersensitivity, and DNA methylation.
  • Development of a new ENCODE Portal with improved search, visualization, and download capabilities.
  • Utilization of comprehensive metadata for data provenance, reusability, and reproducibility.

Main Results:

  • Release of results from nearly 5000 experiments for the scientific community.
  • The new ENCODE Portal offers advanced browsing and searching based on assay metadata and summaries.
  • The portal supports the integration of genomic data from multiple projects.

Conclusions:

  • The ENCODE Project's third phase significantly expands the catalog of human genome functional elements.
  • The revamped ENCODE Portal improves accessibility and usability of ENCODE data, promoting research reproducibility.
  • The platform facilitates integrated analysis of diverse genomic datasets.