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Related Concept Videos

Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.3K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
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RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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Transcription Factors02:16

Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Factors02:16

Transcription Factors

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Co-activators and Co-repressors02:04

Co-activators and Co-repressors

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Co-activators and Co-repressors02:04

Co-activators and Co-repressors

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Related Experiment Video

Updated: Mar 30, 2026

An In Vitro Enzymatic Assay to Measure Transcription Inhibition by GalliumIII and H3 5,10,15-trispentafluorophenylcorroles
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An In Vitro Enzymatic Assay to Measure Transcription Inhibition by GalliumIII and H3 5,10,15-trispentafluorophenylcorroles

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Polyphenol Compound as a Transcription Factor Inhibitor.

Seyeon Park1

  • 1Department of Applied Chemistry, Dongduk Women's University, Seoul 136-714, Korea. sypark21@dongduk.ac.kr.

Nutrients
|November 4, 2015
PubMed
Summary

Polyphenols, like flavonoids, can inhibit key protein dimers involved in cell signaling. This review explores their potential as novel therapeutics by disrupting disease-related transcription factor interactions.

Keywords:
NF-κBc-jun/c-fos (AP-1)c-myc/maxpolyphenol.transcription factorβ-catenin/Tcf

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Last Updated: Mar 30, 2026

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Area of Science:

  • Molecular Biology
  • Pharmacology
  • Drug Discovery

Background:

  • Transcription factor-DNA interactions are crucial in cellular processes and represent significant therapeutic targets.
  • Disrupting protein dimers and DNA complexes can impede transcriptional activation and cell transformation.
  • Natural products, particularly polyphenols, are recognized for their ability to modulate protein-protein and protein-DNA interactions.

Purpose of the Study:

  • To review polyphenol compound inhibitors targeting dimeric transcription factors in intracellular signaling pathways.
  • To highlight the potential of polyphenols as site-directed small molecule inhibitors for therapeutic development.

Main Methods:

  • Literature review of studies on polyphenol compounds and their effects on transcription factor interactions.
  • Focus on inhibitors targeting specific dimeric transcription factors: Activator Protein-1 (AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and β-catenin/Tcf.

Main Results:

  • Polyphenols, including flavonoids, demonstrate inhibitory activity against signaling pathways.
  • Evidence suggests these compounds act as site-directed inhibitors, modulating protein-dimer/DNA interactions.
  • Numerous screening initiatives indicate potential for developing drugs targeting transcription factor interactions.

Conclusions:

  • Polyphenol compounds show promise as inhibitors of dimeric transcription factors implicated in various diseases.
  • Further research into these natural products could lead to novel therapeutic strategies for modulating critical signaling pathways.