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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Related Experiment Video

Updated: Mar 30, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
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[Ketosis prone type 2 diabetes (KPD)].

Luciana Concha L, Pilar Durruty A, Manuel García de Los Ríos A

    Revista Medica De Chile
    |November 5, 2015
    PubMed
    Summary

    Ketosis prone type 2 diabetes presents with severe hyperglycemia and ketoacidosis, mimicking Type 1 diabetes. Patients recover to a Type 2 diabetes state, requiring diet and oral medications to prevent recurrence.

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Diabetes Research

    Background:

    • Ketosis prone type 2 diabetes (KPD) is a distinct clinical entity.
    • KPD shares initial symptoms with Type 1 diabetes mellitus (DM1), including severe hyperglycemia and ketoacidosis.
    • Despite initial presentation, KPD occurs in individuals with a Type 2 diabetes mellitus (DM2) phenotype.

    Observation:

    • KPD is characterized by an acute, reversible beta-cell dysfunction.
    • This dysfunction occurs in the context of underlying insulin resistance.
    • The acute phase is followed by a return to a DM2-like state.

    Findings:

    • Patients with KPD do not require long-term insulin treatment after the acute phase resolves.
    • Management focuses on diet and oral hypoglycemic agents.

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  • There is a significant susceptibility to recurrent acute ketotic decompensations.

    • Implications:

    • Understanding KPD is crucial for accurate diagnosis and appropriate management.
    • Distinguishing KPD from DM1 is essential to avoid unnecessary long-term insulin therapy.
    • Proactive management strategies are needed to prevent future ketotic episodes in KPD patients.