[Morphopathologic study of renal glomeruli in Wistar rats in shock experimentally induced with E. coli]

The present study analyzed the structural and ultrastructural changes observed in the kidneys of Wistar rats inoculated with E. coli bacteria suspended in saline solution. For the study, we divided 64 Wistar rats into 2 groups. Two ml. of the suspension containing 9.5 X 10(10) E. coli 0 group 26 CECT, no. 351 were given to the rats in group A via the oral route. Rats in group B were inoculated with 1 ml. of the same suspension. Structurally, we observed an increased glomerular area caused by the increased number and activation of mesangial cells. These showed developed organoids, podocytes with dilated organoids of the cytoplasmic vacuolar system, and very fine, disorganized pedicels. The parietal cells revealed vacuolized cytoplasm, and the basement membranes of the glomerular capillaries were thickened and arranged in layers. In the lumen of the glomerular, vessels, we observed histiocytic elements on endothelial walls, with large amounts of lysosomal elements and residual bodies. Inoculation of the E. coli suspension causes renal shock, which is more intense when innoculation is via the intraperitoneal route, causing severe changes in organ function.