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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

174
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
174
Allergic Reactions02:06

Allergic Reactions

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Overview
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.3K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

135
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
135
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

149
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
149
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Mar 30, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

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[Anaphylaxis].

Hans-Jørgen Malling, Kirsten Skamstrup Hansen, Lene Heise

    Ugeskrift for Laeger
    |November 5, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Prompt recognition and treatment of anaphylaxis, a severe allergic reaction, are crucial. Epinephrine injection, patient positioning, oxygen, and fluids are life-saving interventions.

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    Area of Science:

    • Allergy and Immunology
    • Emergency Medicine

    Background:

    • Anaphylaxis is a severe, systemic allergic reaction with potential for rapid deterioration.
    • Timely recognition and intervention are critical for patient survival and improved outcomes.

    Purpose of the Study:

    • To outline the essential steps in managing anaphylaxis.
    • To emphasize the importance of prompt treatment for life-threatening allergic reactions.

    Main Methods:

    • Review of established anaphylaxis management protocols.
    • Delineation of appropriate emergency treatment steps, including medication dosages and supportive care.

    Main Results:

    • Intramuscular epinephrine injection is the primary life-saving treatment.
    • Specific dosages are recommended based on patient weight (adults/children >40 kg: 0.3-0.5 mg; children 20-40 kg: 0.3 mg; infants <20 kg: 0.15 mg).
    • Supportive measures include supine positioning with elevated lower extremities, high-flow oxygen, and crystalloid fluid resuscitation.

    Conclusions:

    • Prompt administration of epinephrine is paramount in anaphylaxis management.
    • Appropriate patient positioning and supportive care enhance circulatory and respiratory function.
    • Effective anaphylaxis management requires immediate recognition and intervention.