Related Experiment Videos
Terodiline in the treatment of children with unstable bladders
A L Hellström1, K Hjälmås, U Jodal
1Department of Paediatric Surgery, University of Gothenburg, Sweden.
Insights
Terodiline significantly improved continence in children with urge incontinence compared to placebo. This medication, when combined with bladder training, offers a valuable treatment option for pediatric overactive bladder symptoms.
Area of Science:
- Pediatric Urology
- Pharmacology
- Clinical Trials
Background:
- Urgency and urge incontinence are common in children.
- Unstable bladder is a frequent cause of pediatric incontinence.
- Effective treatment options are crucial for improving quality of life.
Purpose of the Study:
- To evaluate the efficacy of terodiline in treating urge incontinence in children.
- To compare terodiline's effectiveness against a placebo.
- To assess terodiline's impact on bladder capacity.
Main Methods:
- Double-blind, placebo-controlled study.
- Involved 58 children aged 6-14 with unstable bladders.
- Utilized micturition charting, pad tests, and cystometry.
Main Results:
- Both terodiline and placebo improved continence.
- Terodiline (25 mg/day) showed significantly better results than placebo.
- Terodiline increased bladder capacity in patients with subnormal capacity.
Conclusions:
- Terodiline is a valuable adjunct to bladder regimens for pediatric urge incontinence.
- The drug demonstrated good efficacy and a favorable safety profile over 8 weeks.
- Non-specific bladder training also contributed to improvements in the placebo group.
Abstract:
A double-blind study of terodiline compared with placebo was performed in 58 children aged 6 to 14 years with urgency or urge incontinence. All had an unstable bladder at cystometry. A bladder regimen was emphasised during the study. Continence was improved according to micturition charting and a pad test in both groups. Terodiline at 25 mg/day, however, gave significantly better results than placebo. In patients with a subnormal bladder capacity (less than or equal to 150 ml), a significant increase in capacity was recorded on cystometry during medication with terodiline but not with placebo. The improved continence seen in the placebo group was probably due to the non-specific bladder training achieved by the child's increased awareness and adult involvement during treatment. The even better results attained in the terodiline group shows this drug to be a valuable adjunct to a bladder regimen in children with urge incontinence, particularly since no important adverse effects were noted during an 8-week period.