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Updated: Mar 30, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Chronotherapeutic Drug Delivery
Paul Librodo1, Mitchell Buckley, Marilyn Luk
1Department of Pharmacy, Banner Good Samaritan Medical Center, Phoenix, Arizona (Drs Librodo, Buckley, and Luk), and University of Arizona College of Pharmacy, Tucson, Arizona (Mr Bisso).
Abstract:
Living organisms follow a circadian rhythm in which physiological processes such as hormonal secretion, metabolism, heart rate, and renal output are affected by the time of day. Chronotherapy coordinates drug delivery with the circadian rhythm to enhance effectiveness and mitigate adverse effects and is achieved by delivering a drug when the system is most susceptible. Cancer is a chronotherapeutic disorder. Cancer treatment requires high doses of intravenous medication to kill cancerous cells; however, normal cells are also killed, creating intolerable side effects. This review shows that chronotherapy can play a vital role in the quality of life and survival rate for oncology patients.
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