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Related Concept Videos

Appendicitis-I: Introduction01:22

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Related Experiment Video

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
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AIR score assessment for acute appendicitis.

Bruno Von-Mühlen1, Orli Franzon1, Murilo Gamba Beduschi1

  • 1Hospital Regional de São José, São José, SC, Brazil.

Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery
|November 6, 2015
PubMed
Summary

The Appendicitis Inflammatory Response (AIR) score aids in diagnosing acute appendicitis. Elevated C-reactive protein and segmented leukocytes correlate with appendicitis severity, improving diagnostic accuracy.

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Area of Science:

  • Medical diagnostics
  • Surgical pathology

Background:

  • Acute appendicitis is a common cause of acute abdomen, affecting approximately 7% of the population.
  • The Appendicitis Inflammatory Response (AIR) score integrates clinical criteria and laboratory tests for diagnosis.

Purpose of the Study:

  • To evaluate the AIR score for diagnosing acute appendicitis.
  • To assess the AIR score's ability to predict appendicitis severity.

Main Methods:

  • Patients undergoing surgical appendectomy were evaluated.
  • The AIR score was applied to 147 eligible patients (273 total - 126 excluded).

Main Results:

  • C-reactive protein levels showed a direct relationship with appendicitis progression.
  • Percentage of segmented leukocytes in blood count correlated with appendicitis severity.

Conclusions:

  • Serum C-reactive protein is a key laboratory marker for diagnosing appendicitis.
  • Polymorphonuclear leukocyte percentage aids in stratifying appendicitis disease severity.