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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD)
Xinghua Ding1,2, Ruoxu Liu1,3, Wenkai Li2
1State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China.
Abstract:
A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this study showed that there was distinctive metabolic profile for PSD patients. Seven sentinel metabolites showed marked perturbations in PSD patients' blood. The introduction of metabonomics approach may provide a novel metabonomic insight about PSD and the sentinel metabolites for classifying PSD.
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