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Updated: Mar 30, 2026

Models of Bone Metastasis
Published on: September 4, 2012
Mechanisms of osteolytic and osteoblastic skeletal lesions
G David Roodman1, Rebecca Silbermann2
1Department of Medicine, Hematology, Oncology, Indiana University , Indianapolis, IN, USA ; Richard L Roudebush VA Medical Center , Indianapolis, IN, USA.
Abstract:
The bone is a frequent site for tumor metastasis, and cancer in the bone results in marked disturbances of bone remodeling that can be lytic, blastic or a combination of the two. Patients with advanced malignancies that have metastasized to the bone frequently suffer from debilitating skeletal-related events, including pathologic fractures, spinal cord compression syndromes, disorders of calcium and phosphate homeostasis and severe cancer-related pain. This review will discuss recent studies on the mechanisms responsible for osteolytic and osteoblastic metastasis and how their identification has resulted in the development of new agents for patients with metastatic bone disease.
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