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A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
Shin Hye Kim1, Kyoung Huh2, Sungho Won3
1Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine, Seoul, Korea.
Insights
The annual incidence of central precocious puberty (CPP) significantly increased in Korean girls from 2004-2010, while boys showed a smaller rise. Continued monitoring of CPP trends in children is recommended.
Area of Science:
- Pediatric Endocrinology
- Public Health Surveillance
- Growth and Development Disorders
Background:
- Limited data exists on central precocious puberty (CPP) trends in Asian populations.
- This study addresses the knowledge gap by examining CPP prevalence and incidence in Korean children.
Purpose of the Study:
- To assess the prevalence and annual incidence of central precocious puberty (CPP) in Korean children.
- To analyze trends in CPP incidence based on age and gender over a defined period.
Main Methods:
- Utilized data from the Korean Health Insurance Review Agency (2004-2010).
- Reviewed records of 21,351 children diagnosed with CPP or treated with gonadotropin-releasing hormone analogs.
Main Results:
- CPP prevalence: 55.9/100,000 girls, 1.7/100,000 boys.
- Annual incidence in girls rose from 3.3 to 50.4/100,000; boys increased from 0.3 to 1.2/100,000.
- Incidence increased with age in girls (especially ≥6 years) and showed minimal change in boys <8 years.
Conclusions:
- A substantial increase in the annual incidence of CPP was observed in Korean girls over seven years.
- Significant age and gender differences were noted in CPP incidence trends.
- Ongoing surveillance of CPP trends in Korean children is crucial.
Background:
Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children.
Methods:
Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs.
Results:
The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged < 6 years. In contrast, the annual incidence remained relatively constant in boys aged < 8 years, while a small increase was observed only in boys aged 8 years. The increase of annual incidence showed significant differences depending on age and gender (P <0.0001).
Conclusions:
The annual incidence of CPP has substantially increased among Korean girls over the past 7 years. Continued monitoring of CPP trends among Korean children will be informative.
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