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Related Experiment Video

Updated: Mar 30, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Complex strength performance in patients with haemophilia A. Method development and testing.

B Runkel¹, M Kappelhoff, T Hilberg

¹Britta Runkel, Department of Sports Medicine, University of Wuppertal, Pauluskirchstraße 7, 42285 Wuppertal, Tel. 02 02/439 59 13, Fax 02 02/439 59 10,

Hamostaseologie

|November 6, 2015

Summary

Patients with haemophilia (PwH) show significant muscle strength deficits in extremities and back muscles, but not generally. Early complex strength training is recommended for comprehensive haemophilia treatment.

Keywords:

Haemophilia method development strength testing

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Area of Science:

Orthopedics
Sports Medicine
Hematology

Background:

Muscle strength deficits are common in patients with haemophilia (PwH).
Accurate measurement of complex muscle strength is crucial for understanding and managing these deficits.

Purpose of the Study:

To develop and validate a novel complex strength measurement method.
To assess muscle strength differences between PwH and healthy controls using this new method.

Main Methods:

Developed a complex strength measurement protocol.
Recruited 20 severe haemophilia A patients and 20 controls for maximum isometric strength testing.
Assessed reliability through re-test measurements in controls.

Main Results:

The developed method demonstrated high reliability (ICC 0.764–0.934).
PwH exhibited significant strength reductions (19–35%) in triceps brachii, biceps brachii, latissimus dorsi, biceps femoris, and quadriceps femoris.
No significant differences were observed in abdominal or hand strength.

Conclusions:

PwH do not have a general muscle strength deficit.
Deficits are most pronounced in upper/lower extremities and back muscles.
Complex muscle strength training should be integrated early into haemophilia treatment plans.