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Pitfalls in assessing efficacy and side-effects of antidepressants
1Academic Department of Psychiatry, St Mary's Hospital, London, England.
International Journal of Clinical Pharmacology Research
|January 1, 1989
Abstract:
Pitfalls in designing studies to test efficacy of new antidepressants occur in a number of different areas, including the criteria used for selecting patients, the choice of rating instruments for the assessment of severity, the length of treatment and the size of the study. Similarly there are pitfalls in the assessment of the side-effects of a compound. The paper considers each of these pitfalls and also the assessment of risk of adverse drug reactions.