Related Experiment Video
Updated: Mar 30, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Foster Kennedy Syndrome: An Atypical Presentation
Alberto Parafita-Fernández1, Marta Sampil, Carlos Cores
1*MD †MD, PhD Ophthalmology Department, Complejo Hospitalario de Pontevedra, Pontevedra, Spain (AP-F, MS, FJC, EV); and School of Medicine, University of Santiago de Compostela, Spain (CC).
Foster Kennedy syndrome (FKS) typically presents with optic nerve atrophy and edema. This case highlights FKS with optic nerve atrophy and retinal vein occlusion, suggesting a space-occupying lesion.
Area of Science:
- Neuro-ophthalmology
- Neurology
- Ophthalmology
Background:
- Foster Kennedy syndrome (FKS) is a rare condition characterized by unilateral optic nerve atrophy and contralateral optic nerve edema.
- It is typically caused by an intracranial mass compressing the optic nerves and chiasm.
Observation:
- A 56-year-old man presented with hemiretinal retinal vein occlusion in his right eye and prior optic nerve atrophy in his left eye.
- The patient had no cardiovascular or prothrombotic risk factors, prompting investigation into the cause of contralateral optic atrophy.
- Imaging revealed a suprasellar mass, later identified as a meningioma.
Findings:
- This case presented an atypical manifestation of FKS, where retinal vein occlusion replaced the typical optic nerve edema.
- The findings underscore the importance of considering space-occupying lesions in cases of optic atrophy associated with acute ocular pathology.
Implications:
- Diagnostic imaging is crucial for identifying the etiology of optic atrophy when classic symptoms or disease progression are absent.
- Unusual presentations of FKS can be masked by common clinical features, necessitating a high index of suspicion for rare conditions.
Related Concept Videos
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Chronic Kidney Disease II: Clinical Manifestations
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Atypical Pneumonia
Antisocial Personality Disorder
Behavioral Characteristics and...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
