Related Experiment Video
Updated: Mar 30, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Paediatric palliative care: recommendations for treatment of symptoms in the Netherlands
Rutger R G Knops1, Leontien C M Kremer2, A A Eduard Verhagen3
1Department of Paediatric Oncology, Emma Children's Hospital/Academic Medical Centre, PO Box 22660, 1100 DD, Amsterdam, The Netherlands. r.r.knops@amc.uva.nl.
Insights
High-quality pediatric palliative care guidelines are scarce. This study provides recommendations to improve symptom management and reduce suffering for children with life-threatening conditions, aiding caregiver education.
Area of Science:
- Palliative Care
- Pediatric Oncology
- Symptom Management
Background:
- Children with life-threatening illnesses experience significant end-of-life suffering.
- Current symptom control in pediatric palliative care is often inadequate due to caregiver unfamiliarity.
- Clinical practice guidelines are essential for ensuring high-quality pediatric palliative care.
Purpose of the Study:
- To develop high-quality care recommendations for recognizing and relieving symptoms in pediatric palliative care.
- To improve the overall quality of palliative care for children facing life-threatening conditions.
Main Methods:
- Conducted an extensive literature search for guidelines and systematic reviews on pediatric palliative care up to 2011.
- An expert panel synthesized existing evidence and reached consensus on recommendations.
- Utilized adult palliative care evidence and limited pediatric data due to scarcity.
Main Results:
- Identified a significant lack of evidence-based guidelines specifically for symptom treatment in pediatric palliative care.
- Reviewed 21 guidelines and 693 articles, with only four meeting inclusion criteria.
- Relied on two textbooks and an adult palliative care website as primary evidence sources.
Conclusions:
- There is a critical paucity of evidence for treating symptoms in pediatric palliative care.
- A unique set of recommendations was developed by integrating adult palliative care evidence, sparse pediatric data, and expert consensus.
- These recommendations serve as a vital educational tool for caregivers to alleviate symptoms and suffering in children receiving palliative care.
Background:
Children dying of a life threatening disease suffer a great deal at the end of life. Symptom control is often unsatisfactory, partly because many caregivers are simply not familiar with paediatric palliative care. To ensure that a child with a life-threatening condition receives high quality palliative care, clinical practice guidelines are needed. The aim of this study is to improve palliative care for children by making high quality care recommendations to recognize and relieve symptoms in paediatric palliative care.
Methods:
An extensive search was performed for guidelines and systematic reviews on paediatric palliative care up to year 2011. An expert panel combined the evidence with consensus to form recommendations on the treatment of symptoms in paediatric palliative care.
Results:
We appraised 21 guidelines and identified 693 potentially eligible articles of which four met our inclusion criteria. None gave recommendations on the treatment of symptoms in paediatric palliative care. Two textbooks and an adult palliative care website were eventually our main sources of evidence.
Conclusion:
Hardly any evidence is available for the treatment of symptoms in paediatric palliative care. By combining evidence for adult palliative care and the sparse evidence for paediatric palliative care with expert opinion we defined a unique set of high quality care recommendations to relieve symptoms and lessen the suffering of children in palliative care. These results are an important tool to educate caregivers on how to relieve symptoms in children in paediatric palliative care.
Related Concept Videos
Continuing Care
Nursing Ethical Principles II
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Ethical Issues
Ethical Concerns in Healthcare:
