Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensive Rehabilitation With Adjunctive Bilateral Anodal tDCS in Post-Stroke Dysphagia: A Multicenter Randomized Controlled Trial.

European journal of neurology·2026
Same author

Real-world chronic recordings from implantable adaptive deep brain stimulation systems for Parkinson's disease motor state classification.

Frontiers in bioinformatics·2026
Same author

Psychosocial and body image alterations associated with focal dystonia.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Pushing athletic performance boundaries with anodal transcranial direct current stimulation: an exploratory, pilot, randomized controlled study on strength and inflammation in elite weightlifters.

BMC sports science, medicine & rehabilitation·2026
Same author

Effects of Transcutaneous Spinal Direct Current Stimulation on Cognitive and Psychological Outcomes in Multiple Sclerosis: A Preliminary Case Series.

Biomedicines·2026
Same author

Reduced Childhood Outdoor Exposure Raises Pediatric Multiple Sclerosis (PedMS) Risk.

Neurology and therapy·2026

Related Experiment Video

Updated: Mar 30, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.7K

Cerebellar and Motor Cortical Transcranial Stimulation Decrease Levodopa-Induced Dyskinesias in Parkinson's Disease.

Roberta Ferrucci1,2, Francesca Cortese1, Marta Bianchi3

  • 1Fondazione IRCCS Ca' Granda, Milan, Italy.

Cerebellum (London, England)
|November 7, 2015
PubMed
Summary
This summary is machine-generated.

Transcranial direct current stimulation (tDCS) improved levodopa-induced dyskinesias in Parkinson's disease patients. This non-invasive brain stimulation technique offers a potential new treatment for movement disorders by targeting motor cortex and cerebellum.

Keywords:
Cerebellar tDCSCerebellumLevodopa-induced dyskinesiasParkinsontDCS

More Related Videos

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

4.6K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.3K

Related Experiment Videos

Last Updated: Mar 30, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.7K
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

4.6K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.3K

Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting motor function.
  • Levodopa-induced dyskinesias are common motor complications in PD patients.
  • Non-invasive brain stimulation techniques like tDCS are being explored to manage PD symptoms.

Purpose of the Study:

  • To investigate the efficacy of transcranial direct current stimulation (tDCS) on motor and cognitive symptoms in Parkinson's disease.
  • To assess the impact of cerebellar and motor cortex tDCS on levodopa-induced dyskinesias in PD patients.

Main Methods:

  • Nine idiopathic PD patients (aged 60-85) received daily bilateral anodal tDCS (2 mA, 20 min, 5 days) over the cerebellum and motor cortex, or sham tDCS, in a randomized crossover design.
  • Motor function (UPDRS III), dyskinesias (UPDRS IV), and cognitive function were assessed at baseline, end of treatment (Day 5), 1 week, and 4 weeks post-treatment.

Main Results:

  • Anodal tDCS applied over the motor cortex and cerebellum significantly improved the dyskinesia section of the UPDRS IV (p < 0.001).
  • No significant improvements were observed in other motor or cognitive variables with anodal cerebellar tDCS, M1-tDCS, or sham tDCS (p > 0.05).

Conclusions:

  • Daily anodal tDCS applied to the motor cortex and cerebellum for five consecutive days shows preliminary efficacy in reducing levodopa-induced dyskinesias in Parkinson's disease.
  • Despite the small sample size, these findings suggest tDCS as a potential therapeutic option for managing dyskinesias in PD.
  • Further research with larger cohorts is warranted to confirm these results and explore optimal tDCS parameters for PD management.