Gene regulation by long purine tracks in brain related diseases
Himanshu Narayan Singh1, Moganty R Rajeswari2
1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India ; School of Sciences, Noida International University, Gautam Budh Nagar, 203201 Uttar Pradesh, India.
Abstract:
Purine repeats are randomly distributed in the human genome, however, they show potential role in the transcriptional deregulation of genes. Presence of long tracks of purine repeats in the genome can disturb its integrity and interfere with the cellular behavior by introducing mutations and/or triple stranded structure formation in DNA. Our data revealed interesting finding that a majority of genes carrying purine repeats, of length n≥200, were down regulated and found to be linked with several brain related diseases [1]. The unique feature of the purine repeats found in the present study clearly manifests their significant application in developing therapeutics for neurological diseases.
More Related Videos
08:22A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
Published on: December 1, 2017
08:33Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
Published on: March 24, 2019
Related Concept Videos
Neural Regulation
Biosynthesis of Nucleic Acids
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Regulation of Expression at Multiple Steps
lncRNA - Long Non-coding RNAs
