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[Clinical evaluation of CA-50 in cases with colorectal cancer]
Insights
Serum CA-50 levels are elevated in colorectal cancer patients compared to healthy donors. Combining CA-50 with CA 19-9 and CEA assays improves diagnostic value for colorectal cancer detection.
Area of Science:
- Oncology
- Biochemistry
Context:
- Colorectal cancer (CRC) diagnosis relies on various biomarkers.
- Accurate and early detection of CRC is crucial for patient outcomes.
Purpose:
- To evaluate the diagnostic utility of serum carbohydrate antigen 50 (CA-50) in colorectal cancer.
- To assess the correlation of CA-50 with established tumor markers CA 19-9 and CEA.
Summary:
- Serum CA-50 was measured in 67 healthy donors and 46 CRC patients using enzyme immunoassay.
- Mean CA-50 levels were significantly higher in CRC patients (31.7 U/ml) than in healthy donors (10.6 U/ml).
- Overall sensitivity for CRC was 26.1%, with varying sensitivity across stages (I-V).
- Strong correlations were observed between CA-50 and CA 19-9 (r=0.82) and CA-50 and CEA (r=0.51).
Impact:
- Serum CA-50 shows potential as a biomarker for colorectal cancer.
- Combination assays including CA-50, CA 19-9, and CEA may enhance diagnostic accuracy for colorectal cancer.
Abstract:
Serum CA-50 has been evaluated in 67 healthy donors and in 46 patients with a colorectal cancer by an enzyme immunoassay (EIA Kit, Mitsui pharmaceuticals, Inc.). The mean value of the healthy donors (n = 67) was 10.6 +/- 6.1 U/ml and for patients with a colorectal cancer 31.7 +/- 55.2 U/ml. Both in healthy donors and in patients, the mean value was found to be higher in females than males. The overall sensitivity in the colorectal cancer patients was 26.1 percent, the percentages for those in stage I, 20, II, 9.1, III, 40, IV, 20, and V, 50% respectively. In a correlation between serum CA-50 and CA 19-9, the correlation coefficient was 0.82 (p less than 0.01), and in between CA-50 and CEA, 0.51 (p less than 0.01). Thus a combination assay among CA-50, CA 19-9, and CEA has proved to be of significant value in cases of a colorectal cancer.