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[VITAMIN D AND CHRONIC LUNG COLONIZATION IN PEDIATRIC AND YOUNG ADULTS CYSTIC FIBROSIS PATIENTS]
David González Jiménez1, Rosana Muñoz Codoceo2, María Garriga García3
1Gastroenterología y Nutrición Pediátrica. Hospital Universitario Central de Asturias, Oviedo.. domixixon@gmail.com.
Insights
More than half of Cystic Fibrosis patients have insufficient vitamin D levels. Chronic lung infections, particularly by Pseudomonas and Staphylococcus aureus, significantly increase the risk of vitamin D deficiency, even with supplementation.
Area of Science:
- Pediatric Pulmonology
- Nutritional Science
- Microbiology
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs, with chronic lung infections being a major cause of morbidity and mortality.
- Vitamin D deficiency is common in CF patients, potentially impacting immune function and lung health.
- The relationship between vitamin D status and chronic lung colonization in CF requires further elucidation.
Purpose of the Study:
- To evaluate vitamin D status in a cohort of Cystic Fibrosis patients.
- To investigate the association between vitamin D levels and chronic lung colonization by specific pathogens in CF.
- To identify risk factors for vitamin D deficiency in this population.
Main Methods:
- A descriptive, cross-sectional, multicenter study was conducted involving 377 CF patients from November 2012 to April 2014.
- Vitamin D levels were measured, with levels below 30 ng/ml defined as insufficient.
- Chronic colonization was defined as at least two positive sputum cultures within the preceding year.
Main Results:
- 65% of the 377 CF patients exhibited insufficient vitamin D levels.
- An inverse correlation was observed between patient age and vitamin D levels (r = -0.20, p < 0.001).
- Chronic colonization by Pseudomonas sp. in children/adolescents and Staphylococcus aureus in younger children was associated with an increased risk of vitamin D deficiency, independent of age, screening diagnosis, or pancreatic status.
Conclusions:
- Over half of the studied CF patients had suboptimal vitamin D levels despite supplementation.
- Chronic lung colonization by Pseudomonas sp. and S. aureus is a significant risk factor for developing vitamin D deficiency in CF patients.
- Targeted monitoring and intervention for vitamin D status are crucial in CF patients with chronic lung infections.
Introduction And Objectives:
evaluate vitamin D status and its association with chronic lung colonisation in Cystic Fibrosis patients.
Material And Methods:
descriptive cross-sectional multicenter study. From November 2012 to April 2014, at 12 national hospitals, 377 patients with Cystic Fibrosis were included. Vitamin D levels < 30 ng/ml were classified as insufficient. Chronic colonisation was considered if they had at least two positive cultures in the past year.
Results:
the median age was 8.9 years (2 months to 20 years). 65% had insufficient levels of vitamin D. There was an inverse correlation between age and vitamin D levels (r = -0.20 p < 0.001). Those diagnosed by screening, were younger and had higher levels of vitamin D. There was an inverse correlation between the number of colonisations and vitamin D levels (r = -0.16 p = 0.0015). Adjusting for age, pancreatic status and diagnosis by screening, colonization by S. aureus in 6 years, increased the risk of insufficient levels of vitamin D: OR 3.17 (95% CI 1.32 to 7.61) (p = 0.010) and OR 3.77 (95% CI 1.37 to 10 , 37) (p = 0.010), respectively.
Conclusions:
despite adequate supplementation, more than half of our patients did not achieve optimal levels of vitamin D. Regardless of age, diagnosis by screening or pancreatic status, chronic colonization by Pseudomonas sp. in children and adolescents and S. Aureus in infants and preschoolars increases the risk of developing vitamin D deficiency in these patients.
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