Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninvasive whole-brain imaging of glymphatic dynamics.

Science advances·2026
Same author

Machine-learning-based tumor segmentation and classification using dynamic optical contrast imaging for thyroid cancer.

Biophotonics discovery·2026
Same author

Magneto-Plasmonics-Enhanced Colorimetric Lateral Flow Immunoassay Using Magnetic-Gold Nanostars.

ACS applied materials & interfaces·2026
Same author

Direct, Pretreatment-Free Surface-Enhanced Raman Scattering (SERS) Detection of Uric Acid in Urine Facilitated by Efficient Hydrogen Bonding-Driven Capture.

Analytical chemistry·2026
Same author

Rapid Solution-Based SERS Detection of Pesticides Using Graphene Oxide-Coated Silver-Gold Nanostars.

ACS applied nano materials·2026
Same author

Tunable and scalable production of nanostar particle platforms for diverse applications using an AI-integrated automated synthesis system.

Journal of materials science·2026

Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

4.2K

Plasmonic SERS biosensing nanochips for DNA detection.

Hoan T Ngo1,2, Hsin-Neng Wang1,2, Andrew M Fales1,2

  • 1Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

Analytical and Bioanalytical Chemistry
|November 9, 2015
PubMed
Summary
This summary is machine-generated.

This study reviews novel DNA detection methods using plasmonic nanochips and surface-enhanced Raman scattering (SERS) for rapid point-of-care diagnostics. These simple, cost-effective techniques detect genetic biomarkers without sample labeling or washing.

Keywords:
DNA biosensorDNA detectionMolecular sentinel-on-chipMultiplex DNA detectionSurface-enhanced Raman scattering

More Related Videos

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

21.6K

Related Experiment Videos

Last Updated: Mar 30, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

4.2K
A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

21.6K

Area of Science:

  • Nanotechnology
  • Molecular Diagnostics
  • Biophotonics

Background:

  • Point-of-care (POC) molecular diagnostics demand rapid, cost-effective DNA detection methods.
  • Plasmonic nanochip platforms offer a promising avenue for sensitive biosensing applications.

Purpose of the Study:

  • To review DNA detection techniques developed over five years using plasmonic-active nanochip platforms.
  • To highlight the simplicity, cost-effectiveness, and diagnostic utility of these novel methods.

Main Methods:

  • Utilized DNA probes as recognition elements on plasmonic nanochips.
  • Employed surface-enhanced Raman scattering (SERS) for signal detection.
  • Sensing mechanism based on target sequence hybridization altering distance between SERS reporters and nanochip surface.

Main Results:

  • Developed single-step DNA detection techniques: molecular sentinel-on-chip (MSC), multiplex MSC, and inverse molecular sentinel-on-chip (iMS-on-Chip).
  • Demonstrated label-free and wash-free detection by measuring SERS signal changes.
  • Successfully detected host genetic biomarkers for respiratory viral infections and dengue virus gene.

Conclusions:

  • Plasmonic nanochip-based SERS techniques provide simple, rapid, and cost-effective DNA detection for POC diagnostics.
  • The developed methods eliminate the need for target labeling or washing steps, enhancing usability.
  • These techniques show significant potential for medical diagnostics, particularly for infectious disease detection.