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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Contact allergy in cheilitis.

Susan M O'Gorman1, Rochelle R Torgerson2

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

International Journal of Dermatology
|November 9, 2015
PubMed
Summary
This summary is machine-generated.

Recalcitrant non-actinic cheilitis often signals contact allergy. Patch testing revealed fragrances, antioxidants, and preservatives as common triggers, with nearly half of patients diagnosed with allergic contact cheilitis (ACC).

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Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Recalcitrant non-actinic cheilitis can be a manifestation of underlying contact allergy.
  • Identifying the specific allergens is crucial for effective management.

Purpose of the Study:

  • To determine the prevalence of allergic contact cheilitis (ACC) in patients presenting with non-actinic cheilitis.
  • To identify the most significant allergens responsible for ACC in this patient cohort.

Main Methods:

  • Retrospective review of institutional database records for patients with non-actinic cheilitis who underwent patch testing.
  • Analysis of patch test results and electronic medical records from January 2001 to August 2011.

Main Results:

  • Out of 91 patients, 45% were diagnosed with ACC.
  • The most significant allergens identified included fragrance mix, Myroxylon pereirae resin, dodecyl gallate, octyl gallate, and benzoic acid.
  • Nickel emerged as the most prevalent metal allergen.

Conclusions:

  • Contact allergy is a critical factor in managing recalcitrant cheilitis.
  • Fragrances, antioxidants, preservatives, nickel, and gold are key allergens to consider.
  • Patch testing beyond standard oral series is recommended for non-actinic cheilitis evaluation.