Anetoderma in the Setting of a Hematologic Abnormality and COVID-19 Infection

Area of Science:

• Dermatology
• Hematology
• Infectious Diseases

Background:

• Anetoderma is a rare dermatosis characterized by dermal elastic fiber loss.
• While often idiopathic, anetoderma has been linked to various associated conditions, notably prothrombotic abnormalities.

Observation:

• A 79-year-old woman with a heterozygous Factor V Leiden mutation developed anetoderma.
• The onset of anetoderma occurred shortly after a COVID-19 infection.
• The patient's COVID-19 infection was complicated by a thromboembolic event.

Findings:

• This case report details anetoderma occurring in the context of both a viral infection (COVID-19) and a known prothrombotic disorder (Factor V Leiden mutation).
• The patient's presentation suggests a potential association between these factors and the development of anetoderma.

Implications:

• This case contributes to understanding the potential triggers and associations of anetoderma, particularly in patients with underlying prothrombotic conditions.
• Further research may elucidate the mechanisms linking infections, thrombophilia, and elastic tissue abnormalities in dermatological conditions like anetoderma.