Related Experiment Video
Updated: Mar 30, 2026
10:26
Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
Published on: October 21, 2022
2.6K
Extracavitary primary effusion lymphoma: A case report from India
Rajalakshmi Sampath, Marie Therese Manipadam1, Sheila Nair
1Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
Indian Journal of Pathology & Microbiology
|November 10, 2015
Summary
This case report details extracavitary primary effusion lymphoma presenting as jejunal polyps. Diagnosis requires suspecting CD20 negative lymphoma in seropositive individuals, confirmed by specific markers.
Area of Science:
- Oncology
- Pathology
- Virology
Background:
- Extracavitary primary effusion lymphoma (ECPEL) is a rare subtype of non-Hodgkin lymphoma.
- It is associated with the Epstein-Barr virus (EBV).
- ECPEL typically affects serous cavities but can manifest extrinsically.
Observation:
- A 38-year-old man presented with jejunal polyps.
- The polyps were diagnosed as CD20 negative large cell lymphoma with plasmablastic differentiation.
- The patient was seropositive, suggesting a potential viral etiology.
Findings:
- This case represents the first reported instance of ECPEL presenting as jejunal polyps in India.
- The lymphoma exhibited CD20 negativity with plasmablastic/immunoblastic features.
- Immunohistochemistry for latency-associated nuclear antigen-1 and EBV-encoded RNA (EBER) in situ hybridization confirmed EBV association.
Implications:
- Highlights the importance of considering ECPEL in the differential diagnosis of gastrointestinal lymphomas, particularly in EBV-seropositive individuals.
- Suggests that extranodal ECPEL can present atypically as gastrointestinal polyps.
- Emphasizes the utility of specific viral markers for accurate diagnosis of EBV-driven lymphomas.
