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Pineal parenchymal tumor of intermediate differentiation
Meena Patil1, Manjiri Karandikar
1Department of Pathology, B.V.D.U. Medical College, Pune, Maharashtra, India.
Indian Journal of Pathology & Microbiology
|November 10, 2015
Summary
Pineal parenchymal tumor of intermediate differentiation (PPTID) is a rare CNS neoplasm. This case highlights a PPTID with unusual spinal metastasis, underscoring the need for further classification research.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- The 2007 WHO classification introduced Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID) as a distinct entity.
- PPTID classification remains controversial due to limited case reports.
- This tumor type is positioned between pineocytoma and pineoblastoma (WHO grade II or III).
Observation:
- A 25-year-old female presented with chronic headache, nausea, and vomiting.
- Brain imaging revealed a well-defined, mildly enhancing pineal region lesion with calcifications.
- The tumor was surgically excised.
Findings:
- The patient developed rare metastasis in the thoracic and lumbosacral spine three years post-excision.
- This metastatic presentation is an uncommon event for PPTID.
Implications:
- This case underscores the aggressive potential of PPTID, challenging its current classification.
- Further research is crucial to refine the understanding and management of PPTID.
- Highlights the importance of long-term surveillance for patients diagnosed with PPTID.
