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Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

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A nongrading histologic approach to Clark (dysplastic) nevi: A potential to decrease the excision rate.

Daniel F Lozeau¹, Michele J Farber¹, Jason B Lee¹

¹Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Journal of the American Academy of Dermatology

|November 10, 2015

Summary

This summary is machine-generated.

A nongrading approach to diagnosing Clark nevi (dysplastic nevi) resulted in fewer excisions compared to traditional methods. This method maintained a low rate of diagnostic changes, suggesting it is a viable alternative for managing these lesions.

Keywords:

Clark nevus atypia biopsy diagnostic uncertainty dysplastic nevus excision melanoma

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Area of Science:

Dermatopathology
Oncology
Histopathology

Background:

Dysplastic nevi are often treated as melanoma precursors despite limited evidence.
Histologic grading of dysplastic nevi may lead to unnecessary excisions.

Purpose of the Study:

To evaluate a nongrading diagnostic approach for Clark nevi (dysplastic nevi).
To determine the diagnostic uncertainty rate and re-excision outcomes for Clark nevi using this approach.

Main Methods:

A nongrading approach was applied to melanocytic nevi diagnosed between 2007 and 2013.
Diagnostic uncertainty rate was calculated as re-excisions divided by total Clark nevi.

Main Results:

The nongrading approach yielded an 11.1% diagnostic uncertainty/excision recommendation rate.
Melanoma was diagnosed in 2% of the re-excised specimens.

Conclusions:

The nongrading approach for Clark nevi reduces excision rates compared to previous methods.
This approach maintains a low rate of diagnostic change, comparable to grading methods.