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[Growth hormone deficiency in children]

Jon Nielsen, Rikke Beck Jensen, Anders Juul Afdeling

    Ugeskrift for Laeger
    |November 10, 2015
    PubMed

    Insights

    Growth hormone (GH) deficiency can appear at birth or later in childhood, causing growth deceleration. Diagnosis involves auxological measurements, bone age, and biochemical tests for effective treatment.

    Area of Science:

    • Pediatric Endocrinology
    • Growth Hormone Therapy
    • Child Development

    Background:

    • Growth hormone (GH) deficiency can be congenital or acquired, manifesting in infancy or childhood.
    • Early identification of GH deficiency is crucial for timely intervention and optimal growth outcomes.

    Observation:

    • Children with suspected GH deficiency present with short stature and growth deceleration.
    • Diagnostic evaluation includes auxological measurements, bone age assessment, and biochemical testing.

    Findings:

    • GH dosage is optimized every three months, guided by height velocity and serum insulin-like growth factor-I (IGF-I) levels.
    • Treatment aims to normalize growth patterns and achieve appropriate adult height.

    Implications:

    • Effective management of GH deficiency requires ongoing monitoring and dose adjustment.
    • Transitioning care from pediatric to adult endocrinology is essential for long-term GH management after linear growth cessation.

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